COMMENTARY
Pollution
Outdoor air pollution and DNA damage
US Environmental Protection Agency, Research Triangle Park, North Carolina, USA
Correspondence to:
Correspondence to:
Dr D M DeMarini
Environmental Carcinogenesis Division (B143-06), US Environmental Protection Agency, Research Triangle Park, NC 27711, USA; demarini.david@epa.gov
Commentary on the paper by Tovalin et al (see page 230)
Keywords: DNA damage; air pollution; PM2.5; ozone; comet assay
| The first 150 words of the full text of this article appear below. |
Although working outdoors has frequently been considered more healthful than working indoors, a growing literature suggests that outdoor air exposures increase the risk for a variety of diseases, such as asthma, heart disease, and lung cancer.1,2 Consistent with these epidemiological studies are reports using the 32P-postlabelling assay for stable DNA adducts showing that outdoor air causes DNA damage,3 which is a prerequisite for most mutation and cancer. Supporting these observations are hundreds of studies using primarily the Salmonella mutagenicity assay showing that the particulate and volatile fractions of outdoor air are mutagenic.4
As reviewed by Tovalin and colleagues5 in this issue of OEM, a few studies have used the single cell gel electrophoresis (comet) assay to assess DNA damage associated with outdoor air pollution. However, unlike many of the studies using the 32P-postlabelling assay, studies using the comet assay have not included the personal monitoring of pollutants in
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- DNA damage in outdoor workers occupationally exposed to environmental air pollutants
- H Tovalin, M Valverde, M T Morandi, S Blanco, L Whitehead, E Rojas
Occup. Environ. Med. 2006 63: 230-236.[Abstract] [Full Text] [PDF]
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