Occup Environ Med

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS REGISTER
[Advanced]

Occupational and Environmental Medicine 2006;63:776-786; doi:10.1136/oem.2004.019216
Copyright © 2006 by the BMJ Publishing Group Ltd.

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this link to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Add article to my folders
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Castro-Giner, F
Right arrow Articles by Kogevinas, M
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Castro-Giner, F
Right arrow Articles by Kogevinas, M
Topic Collections
Right arrow OEM Education
Right arrowRelevant Article

EDUCATION

Gene–environment interactions in asthma

F Castro-Giner1, F Kauffmann2, R de Cid3, M Kogevinas4

1 Centre for Research in Environmental Epidemiology, Municipal Institute of Medical Research (IMIM), Barcelona, Spain
2 Inserm, U780 Epidemiology and Biostatistics, Villejuif, France, and Université Paris Sud, Faculté de Médecine, IFR69, Villejuif, France
3 Genes and Disease Program, Centre for Genomic Regulation and Universitat Pompeu Fabra, Barcelona, Spain
4 Centre for Research in Environmental Epidemiology, Municipal Institute of Medical Research (IMIM), Barcelona, Spain and Medical School, University of Crete, Heraklion, Greece

Correspondence to:
Correspondence to:
Dr M Kogevinas
Centre for Research in Environmental Epidemiology, Municipal Institute of Medical Reseach (IMIM), 80 Dr Aiguader Rd, Barcelona 08003, Spain; kogevinas@imim.es

Keywords: asthma; genes; environment; occupational; interaction

The first 150 words of the full text of this article appear below.

Asthma is a complex disease with a diverse genetic and environmental component.1 Asthma shows a high level of phenotypic heterogeneity characterised by obstruction of the airways of the lung and is related with atopy, bronchial hyperresponsiveness (BHR), and increased IgE levels. Over the last decades asthma has become a major cause of morbidity in children from developed countries with an estimated prevalence of 5–10%.2–5 It has been estimated that about 300 million persons worldwide have asthma (http://www.ginasthma.com/).

Studies in twins and family studies indicate that the genetic component of asthma is likely to be high,6–9 although the individual genes identified have only modest effects and an unknown pattern of inheritance. The most common chromosomal linkage regions observed in genome-wide linkage studies are 2q14–q32, 5q31–q33, 6p21.3, 7q31, 11q13, 12q14.3–q24.31, 13q14, 14q11.2–q13, 16p21, 17q11.2, and 20p13.1,4 Several asthma and atopy genes have been identified by positional cloning including the genes . . . [Full text of this article]


Relevant Article

Why are manual workers at high risk of upper limb disorders? The role of physical work factors in a random sample of workers in France (the Pays de la Loire study)
M Melchior, Y Roquelaure, B Evanoff, J-F Chastang, C Ha, E Imbernon, M Goldberg, A Leclerc and the Pays de la Loire Study Group
Occup. Environ. Med. 2006 63: 754-761. [Abstract] [Full Text] [PDF]



This article has been cited by other articles:


Home page
Eur Respir JHome page
F. Castro-Giner, M. Kogevinas, M. Machler, R. de Cid, K. Van Steen, M. Imboden, C. Schindler, W. Berger, J. R. Gonzalez, K. A. Franklin, et al.
TNFA -308G>A in two international population-based cohorts and risk of asthma
Eur. Respir. J., August 1, 2008; 32(2): 350 - 361.
[Abstract] [Full Text] [PDF]


Home page
Occup. Environ. Med.Home page
P A Schulte
The contributions of genetics and genomics to occupational safety and health
Occup. Environ. Med., November 1, 2007; 64(11): 717 - 718.
[Full Text] [PDF]


Home page
Eur Respir JHome page
F. Kauffmann and R. Nadif
Candidate interactions
Eur. Respir. J., July 1, 2007; 30(1): 3 - 4.
[Full Text] [PDF]


Home page
Occup. Environ. Med.Home page
K. Palmer
Work in brief
Occup. Environ. Med., November 1, 2006; 63(11): 717a - 717a.
[Full Text] [PDF]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS REGISTER
Terms and conditions relating to subscriptions purchased online  ¦  Website terms and conditions  ¦  Privacy policy
Copyright © 2006 by the BMJ Publishing Group Ltd.