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Dementia seems to be positively associated with living alone, having no social ties, never having married, and psychosocial and physical inactivity decades before diagnosis. One previous case-control study suggests that social relations and activity in mid-life may protect against the later onset of Alzheimer’s disease. Seidler et al (p. 962) have taken the hypothesis one stage further by investigating whether occupational psychosocial factors play a part in the aetiology of dementia. Some 229 cases of dementia were recruited from clinics around Frankfurt-on-Main and compared with population and clinic controls in normal mental health. A structured interview was used to establish work history, and jobs were classified using a job exposure matrix for their demand and control opportunities. Decreased odds ratios were found for jobs classified as being challenging or involving high social demands, whereas a higher odds ratio was found for jobs with greater potential for mistakes.
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