© 2003 BMJ Publishing Group
EDITORIAL
Epidemiology
Epidemiology, biology, and endocrine disrupters
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Keywords: endocrine disrupter; hypospadias
| The first 150 words of the full text of this article appear below. |
For much of the 1990s the plausibility of the endocrine disrupter hypothesis (EDH) as a useful model for the aetiology of a number of disorders of hormonally regulated biological systems in nature, and ultimately the relevance of the EDH to human disease, has preoccupied interested biologists, toxicologists, and epidemiologists. There is an ever increasing battery of evidence for environmental and industrial chemicals, which show evidence of hormonal activity in vitro, and there is considerable observational evidence of sexuality modifying effects of these chemicals in wildlife. Secular trend data in disorders of hormonally controlled physiological systems in humans have also been examined to identify likely candidate human outcomes for endocrine disruption. The now well rehearsed list of such disorders includes testicular cancer (for which there is convincing evidence of a rise in prevalence over the past century); decreasing sperm counts (for which there is less convincing evidence); and also the
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This article has been cited by other articles:
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Younglai, E. V., Holloway, A. C., Foster, W. G.
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