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 | PBN as a possible bladder carcinogen |
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PBN as a possible bladder carcinogen
In their paper updating a previous investigation of the
mortality of workers employed at a factory producing chemicals in North
Wales, Sorahan, Hamilton, and Jackson plead for priority to be given
for studies on the cancer experience of other working populations
exposed to N-phenyl-
-naphthylamine
(PBN).1
It is, therefore, disappointing that the authors made no reference at
all to studies conducted by the British Rubber Manufacturers' Association (BRMA), and others, on rubber workers employed after 1950. These workers would have been exposed to PBN, and to other antioxidants
still in use after the discontinuance (in 1949) of Nonox "S" and
similar compounds contaminated by -naphthylamine (BNA). This
contaminant, a potent human bladder carcinogen, was at a concentration
(2500 ppm) sufficient to double the incidence of bladder cancer in
those exposed.
A particular study2 which singled out a large cohort of
male rubber workers (2577)
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This article has been cited by other articles:
-
Sorahan, T.
(2008). Bladder cancer risks in workers manufacturing chemicals for the rubber industry. Occup Med (Lond)
58: 496-501
[Abstract] [Full Text] -
Parodi, S, Vercelli, M, Stella, A, Stagnaro, E, Valerio, F
(2003). Lymphohaematopoietic system cancer incidence in an urban area near a coke oven plant: an ecological investigation. Occup. Environ. Med.
60: 187-193
[Abstract] [Full Text]
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