ORIGINAL ARTICLES

Lung and other cancer site mortality in a cohort of Italian cotton mill workers

G Mastrangelo¹, E Fadda¹, R Rylander², G Milan¹, U Fedeli¹, M Rossi di Schio¹ and J H Lange³

¹ Department of Environmental Medicine and Public Health, University of Padova, Italy
² BioFact Environmental Health Research Center, Lerum, Sweden
³ Envirosafe Training and Consultants Inc., Pittsburgh, Pennsylvania, USA

Correspondence to:
Giuseppe Mastrangelo, Department of Environmental Medicine and Public Health, University of Padova, Via Giustinianai 2, 35128 Padova, Italy; giuseppe.mastrangelo{at}unipd.it

Background: Several studies report a lower than expected mortality in lung cancer among workers exposed to organic dust. Recent studies also reported a decreased risk for cancer at other sites.

Objectives: To evaluate the mortality from lung and other cancer sites in cotton mill workers.

Material and methods: A cohort of 3961 Italian cotton mill workers was divided into those working with carding (exposed to high levels of endotoxin-containing cotton dust) and other tasks, which generally have lower exposure. Standardised mortality ratios (SMRs), with 95% confidence intervals (CI), were calculated using death rates of the regional general population as a reference. Cancer mortality was analysed in relation to the length of employment in the two task groups. An internal analysis was also performed through Poisson regression.

Results: Among workers in carding departments, lung cancer SMRs were 1.88 (CI: 0.69 to 4.08), 1.01 (CI: 0.20 to 2.94) and 0.22 (CI: 0.00 to 1.24), respectively, for <6, 6–12 and >12 years of employment (² for trend = 5.45; p<0.05). A significant (p = 0.04) trend was confirmed by Poisson regression. No reduced risks were found for other forms of cancer, nor for those working with other tasks.

Conclusions: The results support previous reports that a high and prolonged exposure to cotton dust and other endotoxin-containing organic dusts is related to a lower risk of lung cancer. There was no indication of a reduced risk for other forms of cancer.

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