ORIGINAL ARTICLE

A case–control study of farming and prostate cancer in African-American and Caucasian men

Tamra E Meyer¹, Ann L Coker¹, Maureen Sanderson², Elaine Symanski¹

¹ University of Texas School of Public Health at Houston, Texas, USA
² University of Texas at Houston School of Public Health at Brownsville, Texas, USA

Correspondence to:
MsT E Meyer
University of Texas Health Science Center at Houston, School of Public Health, 1200 Herman Pressler, Suite E-625 Houston, TX 77030, USA; tamra.e.meyer{at}uth.tmc.edu

Objective: To determine the risk of prostate cancer associated with farming by duration, recency and specific activities among African-Americans and Caucasians.

Methods: This population-based case–control study had information on farming-related activities for 405 incident prostate cancer cases and 392 controls matched for age, race and region in South Carolina, USA, from 1999 to 2001. Cases with histologically confirmed, primary invasive prostate cancer who were aged between 65 and 79 years were ascertained through the South Carolina Central Cancer Registry. Appropriately matched controls were identified from the Health Care Financing Administration Medicare Beneficiary File. Data were collected using computer-assisted telephone interviewing, and adjusted odds ratios (aOR) were estimated using unconditional logistic regression.

Results: Farming was associated with increased risk of prostate cancer in Caucasians (aOR 1.8; 95% confidence interval (CI) 1.3 to 2.7) but not in African-Americans (aOR 1.0; 95% CI 0.6 to 1.6). Regarding specific farming activities, farmers who mixed or applied pesticides had a higher risk of prostate cancer (aOR 1.6; 95% CI 1.2 to 2.2). Increased risk of prostate cancer was observed only for those farming <5 years.

Conclusions: Increased risk of prostate cancer for farmers in this study may be attributable to pesticide exposure. Racial differences in the association between farming and prostate cancer may be explained by different farming activities or different gene–environment interactions by race.

Abbreviations: aOR, adjusted odds ratio; BMI, body mass index; BPH, benign prostatic hyperplasia; CI, confidence interval; DRE, digital rectal examination; HCFA, Health Care Financing Administration; OR, odds ratio; PSA, prostate-specific antigen; REF, reference; SCCR, South Carolina Central Cancer Registry

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

Relevant Article

Farming and prostate cancer

Vilhjalmur Rafnsson
Occup. Environ. Med. 2007 64: 143. [Extract] [Full Text] [PDF]

This article has been cited by other articles:

• Diamanti-Kandarakis, E., Bourguignon, J.-P., Giudice, L. C., Hauser, R., Prins, G. S., Soto, A. M., Zoeller, R. T., Gore, A. C. (2009). Endocrine-Disrupting Chemicals: An Endocrine Society Scientific Statement. Endocr. Rev. 30: 293-342 [Abstract] [Full Text]  
• Prins, G. S (2008). Endocrine disruptors and prostate cancer risk. Endocr Relat Cancer 15: 649-656 [Abstract] [Full Text]  
• Rafnsson, V. (2007). Farming and prostate cancer. Occup. Environ. Med. 64: 143-143 [Full Text]  
• Palmer, K. (2007). Work in brief. Occup. Environ. Med. 64: 141-141 [Full Text]