ORIGINAL ARTICLE

Incidence of dimethylacetamide induced hepatic injury among new employees in a cohort of elastane fibre workers

C-Y Lee¹, S-J Jung¹, S-A Kim¹, K-S Park², B-G Ha¹

¹ Department of Occupational and Environmental Medicine, Gumi CHA Medical Center, College of Medicine, Pochon CHA University, Gumi, Korea (South)
² Department of Preventive Medicine, College of Medicine, Gyeongsang National University, Jinju, Korea (South)

Correspondence to:
Dr C-Y Lee
855 Hyeonggok 1-dong Gumi-si Gyeongsangbuk-do, Seoul 730-728, Korea; ycy4{at}korea.com

Objective: To investigate the incidence of N,N-dimethylacetamide (DMA) induced hepatic injury among new elastane fibre workers and to explore factors relating to DMA induced hepatic injury.

Methods: Elastane fibre workers exposed to DMA were monitored for hepatic injury. Four hundred and forty new workers employed from 1 January 2002 to 31 July 2004 were included as study subjects. DMA exposure estimates were based on urinary N-methylacetamide (NMA) concentrations.

Results: There were 28 cases of DMA induced hepatic injury. The overall incidence of DMA induced hepatic injury among new elastane fibre workers was 0.089/person-year. Incidence rates were 7–10 times higher in high exposure groups than in low exposure groups. Fewer DMA induced hepatic injuries occurred among workers employed for a longer period. Workers whose exposure duration was more than seven months showed no hepatic injury in either the high or low exposure groups. Exposure category and duration of employment were significant variables in the multiple logistic regression analysis.

Conclusions: Results suggest the existence of dose dependent DMA induced hepatic injury. The inverse relation between the incidence of DMA induced hepatic injury and duration of employment may reflect a type of healthy survivor effect or tolerance to DMA induced hepatic injury.

Abbreviations: ALT, alanine transaminase; AP, alkaline phosphatase; AST, aspartate transaminase; DIHI, dimethylacetamide induced hepatic injury; DMA, N,N-dimethylacetamide; DMF, dimethylformamide; GGT, gamma glutamyl transpeptidase; NMA, N-methylacetamide; TLV, threshold limit value

Keywords: dimethylacetamide; incidence; hepatotoxicity; healthy worker effect

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