SHORT REPORT

Fever and neutrophilic alveolitis caused by a vanadium based catalyst

O Vandenplas¹, F Binard-Van Cangh², J Gregoire², A Brumagne², A Larbanois¹

¹ Service de Pneumologie, Cliniques Universitaires de Mont-Godinne, Université Catholique de Louvain, Yvoir, Belgium
² Fonds des Maladies Professionnelles, Brussels, Belgium

Correspondence to:
Correspondence to:
Dr O Vandenplas, Service de Pneumologie, Cliniques Universitaires de Mont-Godinne, B5530 Yvoir, Belgium;
olivier.vandenplas{at}pneu.ucl.ac.be

Aims: To investigate a worker who experienced systemic and respiratory symptoms when exposed to a vanadium containing powder used as a catalyst in the production of maleic anhydride.

Methods: The investigation included inhalation challenge with the suspected compound combined with monitoring of lung function tests and post-challenge bronchoalveolar lavage.

Results: Exposure to the vanadium containing catalyst for 120 minutes resulted in a sustained decline in forced vital capacity and forced expiratory volume in one second, while the transfer factor for carbon monoxide did not change significantly. The subject developed fever and peripheral blood neutrophilia. Bronchoalveolar lavage performed 48 hours after the end of challenge exposure showed a marked increase in neutrophils (60% of total cell count).

Conclusions: Exposure to vanadium can cause a metal fume fever-like syndrome associated with neutrophilic alveolitis.

Keywords: alveolitis; bronchial provocation tests; occupational disease; metal fume fever; vanadium

Abbreviations: FEV, forced expiratory volume; FVC, forced vital capacity

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