Short report
Stimulation of IL-8 release from epithelial cells by gas cooker
PM10: a pilot study
C A J Dicka, M Dennekampb, S Howarthb, J W Cherrieb, A Seatonb, K Donaldsona, V Stonea
a Napier University,
School of Life Sciences, 10 Colinton Road, Edinburgh, EH10 5DT,
Scotland, UK, b University of Aberdeen, Department of
Environmental and Occupational Medicine, Aberdeen, AB25 2ZD,
Scotland, UK
Correspondence to: Dr C A J Dick c.dick{at}napier.ac.uk
Accepted 19 October
2000
OBJECTIVE
To measure
the effect of matter collected by a method that has a 50% efficiency
for particles with an aerodynamic diameter of 10 µm
(PM10), generated by gas and electric cooking, on A549 epithelial cells with and without nitrogen dioxide (NO2).
METHODMultiple indoor
PM10 samples were collected on Teflon filters during the
use of gas or electric cookers. Interleukin-8 (IL-8) concentrations
were measured with a sandwich enzyme linked immunosorbent assay (ELISA) system.
RESULTSTreatment of
A549 cells with PM10 generated from gas cooking resulted in
increased concentrations of IL-8 compared with untreated cells;
particles from the electric cooker had no effect. NO2 did not alter the concentration of IL-8.
CONCLUSIONPM10
generated by gas cooking has the potential to cause proinflammatory
effects in lung cells. This may have implications for susceptible people.
Keywords: indoor air pollution; PM10; interleukin-8
© 2001 by Occupational and Environmental Medicine
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