Lung and bladder cancer among workers in a Norwegian aluminium reduction plant
Pål Romundstada b, Tor Haldorsena, Aage Andersena
a The Cancer Registry
of Norway, N-0310 Montebello, Oslo, Norway, b Department of Occupational Medicine, University
Hospital of Trondheim, Trondheim, Norway
Correspondence to: Pål R Romundstad pr{at}kreftreg.no
Accepted 10 March 2000
OBJECTIVE
To
investigate the relation between exposure to polycyclic aromatic
hydrocarbons (PAHs) and the incidence of lung and bladder cancer among
aluminium production workers.
METHODSThe cohort
comprised 1790 men employed for more than 5 years at a Norwegian
aluminium plant contributing 36 587 person-years to the study.
Historical exposure to PAHs was estimated by the use of industrial
hygiene measurements and by a panel of three people familiar with the
industry. Cancer incidence was investigated from 1953 to 1995. The
observed cases of cancer among men were compared with expected numbers
calculated from national rates for men, and dose-response relations
were investigated by internal comparison by Poisson regression with
age, period, smoking, and cumulative exposure included in the models.
The effect of lagging exposure by 10, 20, and 30 years was also investigated.
RESULTThe
present study showed no increased risk of urinary bladder cancer or
lung cancer with increasing cumulative exposure to PAHs. No significant
changes in risk were found for different lag times.
CONCLUSIONSDue
to the small size of this study, a minor increase in risk could not be excluded.
Keywords: cancer incidence; polycyclic aromatic hydrocarbons; Søderberg
© 2000 by Occupational and Environmental Medicine
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This article has been cited by other articles:
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Bosetti, C, Boffetta, P, La Vecchia, C
(2007). Occupational exposures to polycyclic aromatic hydrocarbons, and respiratory and urinary tract cancers: a quantitative review to 2005. Ann Oncol
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