Short report
Asbestosis and lobar site of lung cancer
William Weiss
Emeritus Professor
of Medicine, MCP Hahnemann University, Philadelphia, PA 19102, USA
Correspondence to: Dr William Weiss, 3912 Netherfield Road, Philadelphia, PA 19129-1014, USA
Accepted 19
January 2000
OBJECTIVE
To assess
the evidence for the hypothesis that lung cancer has a predilection for
the lower lobes in workers with asbestosis.
METHOD
A review of the
available literature with relevant information.
RESULTS
Six published
reports were analysed. In four studies limited to series of cases with
diagnoses of asbestosis, three showed lower lobe predominance of lung
cancer whereas the fourth study included cases in which the
radiographic readings did not meet the usual criterion of profusion for
asbestosis. One cohort study showed lower lobe predominance; the other
reported only 33% lower lobe cancers compared with 20% in unexposed controls.
CONCLUSION
There is
some support for the hypothesis but more studies are needed.
Keywords: asbestos; asbestosis; lung cancer
© 2000 by Occupational and Environmental Medicine
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