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Occupational and Environmental Medicine 2000;57:358; doi:10.1136/oem.57.5.358
Copyright © 2000 by the BMJ Publishing Group Ltd.
Occup Environ Med 2000;57:358 ( May )

Short report

Asbestosis and lobar site of lung cancer William Weiss

Emeritus Professor of Medicine, MCP Hahnemann University, Philadelphia, PA 19102, USA

Correspondence to: Dr William Weiss, 3912 Netherfield Road, Philadelphia, PA 19129-1014, USA

Accepted 19 January 2000

OBJECTIVE---To assess the evidence for the hypothesis that lung cancer has a predilection for the lower lobes in workers with asbestosis.
METHOD---A review of the available literature with relevant information.
RESULTS---Six published reports were analysed. In four studies limited to series of cases with diagnoses of asbestosis, three showed lower lobe predominance of lung cancer whereas the fourth study included cases in which the radiographic readings did not meet the usual criterion of profusion for asbestosis. One cohort study showed lower lobe predominance; the other reported only 33% lower lobe cancers compared with 20% in unexposed controls.
CONCLUSION---There is some support for the hypothesis but more studies are needed.


Keywords: asbestos; asbestosis; lung cancer


© 2000 by Occupational and Environmental Medicine

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