Occup Environ Med 2000;57:818-822 ( December )

Daily concentrations of air pollution and plasma fibrinogen in London

J Pekkanen^a, E J Brunner^b, H R Anderson^c, P Tiittanen^a, R W Atkinson^c

^a Unit of Environmental Epidemiology, National Public Health Institute, PO Box 95, FIN-70701 Kuopio, Finland, ^b International Centre for Health and Society, Department of Epidemiology and Public Health, University College London Medical School, London WC1E 6BT, UK, ^c Department of Public Health Sciences, St George's Hospital Medical School, Cranmer Terrace, London, SW17 0RE, UK

Correspondence to: Dr Juha Pekkanen Juha.Pekkanen{at}ktl.fi

Accepted 25 July 2000

OBJECTIVESThe reason for the association between air pollution and risk of cardiovascular diseases is unknown. The hypothesis was examined that daily concentrations of air pollution are associated with daily concentrations of fibrinogen, a risk factor for cardiovascular disease.
METHODSData on concentrations of plasma fibrinogen for 4982 male and 2223 female office workers, collected in a cross sectional survey in London between September 1991 and May 1993, were combined with data on concentrations of air pollution during the day of blood sampling and during the 3 preceding days.
RESULTSAfter adjustment for weather and other confounding factors, an increase in the 24 hour mean NO₂ during the previous day from the 10th to the 90th percentile (61.7 µg/m³) was associated with a 1.5% (95% confidence interval (95% CI) 0.4% to 2.5%) higher fibrinogen concentration. The respective increase for CO (1.6 mg/m³) was 1.5% (95% CI 0.5%, 2.5%). These associations tended to be stronger in the warm season (April to September). Significant associations were found for black smoke and particulate matter of diameter 10 µm (PM₁₀) only in the warm season. No association with fibrinogen was found for SO₂ or ozone.
CONCLUSIONSThe short term association between air pollution, possibly from traffic, and risk of cardiovascular events may be at least partly mediated through increased concentrations of plasma fibrinogen, possibly due to an inflammatory reaction caused by air pollution.


Keywords: air pollution; fibrinogen; haemostatic factors

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© 2000 by Occupational and Environmental Medicine
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