Dermal in vitro penetration of methiocarb, paclobutrazol, and pirimicarb
Jesper B Nielsen, Flemming Nielsen
Institute
of Public Health, University of Southern Denmark, Winsløwparken 17, DK-5000 Odense C, Denmark
Correspondence to: Dr Jesper B Nielsen jbnielsen{at}health.sdu.dk
Accepted 18 July 2000
OBJECTIVES
The
dominant route of occupational exposure to pesticides in horticulture
is dermal. However, preventive measures are seldom used when handling
plant cultures recently treated with pesticides, thus causing
significant dermal exposure and potential absorption. Assessment of
exposure often depends on biological monitoring of blood or urine
samples. The skin often acts as a temporary reservoir for chemicals
before absorption. Failure to consider the lag time between dermal
exposure and appearance of pesticide or metabolites in the general
circulation may lead to false conclusions about assessment of exposure.
METHODSIn
an experimental model in which in vitro static diffusion cells were
mounted with human skin, dermal penetration of three extensively used
pesticides (methiocarb, paclobutrazol, pirimicarb) was evaluated.
RESULTSPirimicarb
and paclobutrazol had comparable rates of dermal penetration and lag
times of around 18 hours. Methiocarb had a considerably shorter lag
time. Dermal penetration continued for extended periods after exposure
had ended.
CONCLUSIONSWith
lag times sometimes considerably longer than a normal working day,
biological monitoring at the end of exposure may seriously underestimate the actual exposure. There may be implications for regulatory guidelines, which often require only 24 hour observation periods.
Keywords: dermal penetration; pesticides; in vitro
© 2000 by Occupational and Environmental Medicine
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
-
NIELSEN, J. B., NIELSEN, F., SORENSEN, J. A.
(2004). In Vitro Percutaneous Penetration of Five Pesticides--Effects of Molecular Weight and Solubility Characteristics. ANN OCCUP HYG
48: 697-705
[Abstract] [Full Text] -
Brand, R. M, Pike, J., Wilson, R. M, Charron, A. R
(2003). Sunscreens containing physical UV blockers can increase transdermal absorption of pesticides. Toxicol Ind Health
19: 9-16
[Abstract]
- Full Text
- Full Text (PDF)
- Submit a response
- Alert me when this article is cited
- Alert me when eLetters are posted
- Alert me if a correction is posted
Services
- Email this link to a friend
- Similar articles in this journal
- Similar articles in PubMed
- Add article to my folders
- Download to citation manager
- Request Permissions
Citing Articles
Google Scholar
PubMed
Topic Collections
Bookmark with
Register for free content
The full back archive is now available for all BMJ Journals. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006 right back to volume 1 issue 1. Register here to access the free archive of all BMJ Journals.
Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.
